Maternal obesity affects neonatal adipogenesis
نویسندگان
چکیده
منابع مشابه
[Obesity, adipogenesis and insulin resistance].
Insulin resistance precedes the development of type 2 diabetes mellitus and is also a common denominator in the so-called metabolic syndrome. Although the cause of insulin resistance has not been fully elucidated, it seems clear that lifestyle changes, including little physical exercise and constant access to food, particularly in developed and economically emergent countries, as well as geneti...
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The current global diabetes epidemic is driven by obesity. However, many obese individuals do not develop insulin resistance or the metabolic complications. Inappropriate expansion of the subcutaneous adipose cells leads to hypertrophic obesity characterized by a dysregulated adipose tissue with insulin resistance and inflammation. Here, we discuss the limited expandability of the subcutaneous ...
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Nowadays, obesity rates have an increasing tendency, since the incidence of obesity in both developed and developing countries is still rising over the years. Maternal pre-pregnancy obesity seems to have an influence on both obstetrical and neonatal outcomes. Many researchers have focused on pregnancies of obese nulliparous, non diabetic women as well as on the medical profile of their neonates...
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Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, ...
متن کاملIncreasing maternal obesity is associated with alterations in both maternal and neonatal thyroid hormone levels
OBJECTIVE Obesity is associated with alterations in thyroid hormone (TH) levels in obese, pregnant individuals. The maintenance of TH levels throughout gestation is important for proper foetal development. The aim of this study was to measure levels of fT3, fT4 and TSH in maternal and matched cord blood serum from normal weight, overweight and obese gravidae to determine alterations in maternal...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2015
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2015.225